Gauging the value of center Tyson Chandler has never been the easiest basketball exercise.The 17-year veteran has made his name in the NBA as a stellar rim protector, earning the Defensive Player of the Year award in 2011-12. But looking solely at his work on the defensive side of the ball would be selling him a bit short, given how well he has served as a lob specialist and a vertical floor-spacer in pick-and-roll situations.And then, of course, there’s the fact that Chandler — the newest member of the Lakers after a buyout from the Phoenix Suns — is perhaps the best player in NBA history at securing rebounds … without actually securing them.The cerebral 36-year-old has long excelled at what should be known as Tyson Tapbacks: volleyball-like plays in which he swats his club’s misfires toward half-court, where his teammates are more likely to come up with the ball. FiveThirtyEight reviewed every offensive rebound Chandler has obtained since the start of the 2013-14 season1Regular season only. and found that he has generated at least 140 tapbacks in that span. In other words, about 15 percent of his offensive boards during the past five-plus years have stemmed from this play.Video Playerhttps://fivethirtyeight.com/wp-content/uploads/2018/11/TysonTapbacks.mp400:0000:0003:30Use Up/Down Arrow keys to increase or decrease volume.The natural question, of course, is how someone would become so good at such a counterintuitive skill, given that players would obviously prefer to grab misses with both hands. Chandler has suggested that he stumbled onto the strategy.“Once I started getting double-teamed and boxed out, I realized, ‘OK, I can’t get to my full jump — I’ll be getting over-the-back calls all the time,’” the 7-foot-1 Chandler wrote in The Players’ Tribune a few years back. “So I started jumping like I do on a jump ball and batting it with one hand to my teammates. Now it’s funny because I see other big men do it.” In the same piece, Chandler also mentioned that rebounding that way likely cost him from a statistical standpoint for some years, as scorekeeping officials probably weren’t initially crediting him with boards for his backtaps.2With this in mind, FiveThirtyEight’s analysis covers only plays in which Chandler was credited with having snagged an offensive rebound.Chandler, who’s used this method for the better part of a decade, isn’t alone with his unusual, hard-to-track rebounding style. The move is a distant cousin of a strategy employed by Hall of Famer and NBA rebounding legend Dennis Rodman, who would often tip rebounds to himself while in traffic until he could secure the ball. Retired Pistons star Ben Wallace, also one of the best rebounders of all time, used the strategy every so often, too. And players like Brook and Robin Lopez have collected defensive accolades in recent years despite grabbing relatively few boards because they box out so well — an unselfish approach that boosts their teammates’ rebounding stats.Chandler certainly doesn’t lack ability as a traditional offensive rebounder. He’s still elite at generating offense from teammates’ misses — his career offensive rebound percentage ranks third among active players — and he has finished in the NBA’s top 10 in putback frequency3Tracking the share of a player’s offense that stems from a shot attempt immediately after securing an offensive rebound. Minimum of 75 putback possessions required. each of the past three seasons, according to Synergy Sports.It’s worth noting that not all of Chandler’s tapback efforts will be successful. (Laker fans, of course, have fond memories of the sport’s most infamous tapback, when Vlade Divac tipped the ball out to Robert Horry, who hit a game-winning three in the Western Conference finals.) Every now and then, he may toss one out of bounds by mistake, or throw one into the hands of a defensive player who happens to be in better position than one of Chandler’s teammates.But there are indications that Chandler’s tapback rebounds may carry a bit more weight than a typical offensive rebound.Chandler has already displayed clutch timing with his signature play — he’s come up with huge tapbacks already for the Lakers in the last four minutes of games against Miami, Atlanta and Minnesota. But the play also often creates high-value shots for teammates because of how flustered it leaves opponents, who have already crashed the defensive glass and aren’t in ideal position to run out and contest perimeter shooters.Video Playerhttps://fivethirtyeight.com/wp-content/uploads/2018/11/TapbacksIntoBuckets.mp400:0000:0003:11Use Up/Down Arrow keys to increase or decrease volume.An analysis of Big Data Ball play-by-play logs shows that the offensively challenged Suns launched shot attempts a tenth of a second quicker than league average — and shot 3 points of effective field goal percentage better than usual4Going from a 43.4 percent effective field goal rate to a 46.5 percent effective field goal rate. — following a nonputback offensive rebound while Chandler was on the court5So excluding attempts that were within 2 feet of the basket or within 2 seconds of the offensive board. last season. The improved efficiency may have been at least partly due to the extra space shooters enjoyed from Chandler’s occasional tapbacks.And while the one-time All-Star has already proven his worth to the Lakers, who have gone 5-1 since signing Chandler, there are reasons to think that they could benefit from more of the Tyson Tapback. Entering Tuesday night, the club ranked ninth in jump-shooting6Meaning shots ranging from 10 to 35 feet. efficiency when the closest defender was at least 4 feet away. By contrast, the Lakers rank 21st when defenders are any closer than that, according to Second Spectrum. So it might be best for Los Angeles to get more open looks from outside.With time, the Lakers could even benefit from better understanding Chandler’s tapback patterns. In December 2012, Chandler told his teammates on the Knicks during a late-game timeout against the Nets to be prepared for him to tap the ball toward the perimeter on a miss.“I told the guys before we went out there I was getting grabbed and held down. I said, ‘I can’t come up with the rebound, so be ready. Don’t run away so quick because I’m probably going to get my hands on it and tap it out. So be ready to retrieve it,’” he said. Then, like clockwork, Chandler tapped out a rebound to get the Knicks an extra possession, and Jason Kidd — who had won the 2011 title in Dallas with Chandler — hit a game-winning triple on the next sequence.So while Chandler’s 3 points per game might make it easy to overlook his impact on that side of the ball, keep in mind that his value — even on the offensive end — generally goes far beyond that.Neil Paine contributed to this article.Check out our latest NBA predictions.
The Ohio State women’s volleyball team is all about breaking records. This is the first season since 2006 that the Buckeyes have recorded 20 wins. They are 20-7 overall. Their eight conference wins are their most since the 2006 season.The Buckeyes started the season at No. 120 in the NCAA RPI rankings and have climbed to No. 25. The numbers are evidence enough of the growth of the team. The Big Ten and the Pac-10 continue to produce the most competitive women’s volleyball teams. The Big Ten has seven teams in the Top 30, while the Pac-10 sports six Top 30 teams. The Buckeyes defeated Iowa 3-1 and Wisconsin 3-0, both on the road last weekend, climbing to fifth in the Big Ten standings. During the Iowa match, Katie Dull became the 17th Buckeye to break 1,000 career kills. OSU coach Geoff Carlston does not expect her to slow down any time soon.“She is a highly motivated kid and knows she has lots of room to grow. She won’t slow down,” Carlston said.Senior Kristen Dozier’s performance against Wisconsin earned her Buckeye Athlete of the Week honors. Dozier had a match-high 11 blocks, 3 solo and 8 assisted. That set a season high for her, and the 11 blocks fell just two short of her career-high 13 blocks, set in 2006. She scored a team-high 14 points against Wisconsin. Senior Chelsea Noble’s list of honors continues to grow. She has been named a third-team selection on the ESPN Academic All-District IV squad. Noble has started at libero every match this season, leading the team with 703 digs. On Friday, the Buckeyes host Northwestern, a team they beat 3-0 in the start of conference play. Carlston expects the Wildcats to come in with confidence.The Buckeyes take on No. 5 Illinois Saturday. They lost to Illinois, 3-1, in their first conference game of the season.The Buckeyes will have to be aggressive offensively against Illinois, because they do not make a ton of mistakes, Carlston said.“They are steady and we have to beat them,” he said. Two former OSU volleyball players will return this weekend as assistant coaches at Illinois and Northwestern. Kristen Jensen played for the Buckeyes in 1992-1995 and is the assistant coach at Northwestern. Fellow Buckeye Jen Flynn (Oldenberg) led the Buckeyes from 1996-1999 and is the assistant coach at Illinois. The Buckeyes face Northwestern 8 p.m. Friday at St. John Arena. They play Illinois 2 p.m. Sunday at St. John Arena.
For the past three years, Washington has been seemingly led by senior quarterback Jake Browning, who threw for 43 touchdowns in 2016, earning the Huskies a College Football Playoff appearance and himself a sixth-place finish in Heisman voting, the second-highest in Huskies history.But as Browning’s numbers have declined since his sophomore year — he threw 16 touchdowns and 10 interceptions this season — senior running back Myles Gaskin provided the consistency Washington has needed to stay strong on the offensive side.Redshirt junior defensive tackle Dre’Mont Jones understands this.“I see a team that really relies on their running backs to get them going. I see No. 9, he’s really, I guess, the kick starter for their team, seems like, my point of view, and he’s really talented,” Jones said.Gaskin, No. 9 on Washington, has been the backbone for the Huskies, rushing for 1,147 yards and 10 touchdowns this season in 11 games. Gaskin missed two games in 2018 due to a shoulder injury, one of which ended up becoming a 12-10 loss to Cal.The senior running back originally went down against Oregon, playing minimal snaps in the second half against the Ducks, which Washington ended up losing 30-27 in overtime.Gaskin has received back-to-back second-team All-Pac 12 honors, and is Washington’s leader in career rushing yards and total touchdowns.Even with all of the accolades coming down to one final game, Gaskin said he is not yet reflecting on his time at Washington.“I probably should, but I think I’m going to wait until after the season, maybe a couple years from now,” Gaskin said. “I think I’m just kind of having a lot of fun right now. So there’s no reason to reflect on anything right now. Just enjoy it all, and then once it’s all over, then reflect.”Ohio State defensive coordinator Greg Schiano called Washington’s running back group as good as the team has seen all season.“It’s a complete offense. There’s not a position group that you look at and say, ah, that’s a weakness. There really isn’t,” Schiano said.Browning may be the player on the mind when it comes to Washington’s offense, but Gaskin has the potential to exploit the largest weakness, according to Schiano, on Ohio State’s defense: allowing big-yardage plays.“The biggest thing that stands out is the long runs,” Schiano said. “I’ve never had long runs like this in my career. And for a lot of different reasons.”Gaskin has runs of 25 yards or more in five of his 11 games this season, and in 12 of his past 24 matchups. The 5-foot-10, 193-pound back has the speed and ability to make Ohio State pay for struggling on stopping the long runs.For Gaskin, he said it’s not as much about the big plays — 38 plays allowed of 30 yards or more — but instead, how the Buckeyes respond to those plays, that he pays attention to.“Everybody is going to have their plays, but just kind of seeing the defense always ready to bounce back and play better from that play or learning from what happened in that play … I feel like that’s huge.” Gaskin said. “I feel like that’s what we’ve got to be ready for and just be ready to fight.”The responsibility of the big plays has fallen to Ohio State’s linebackers at times this season, with gaps being open for teams like Maryland and Oregon State to exploit for huge gains up the middle.Redshirt sophomore linebacker Tuf Borland understands what Gaskin brings to the table, citing his ability to wait and explode through the gap as his major selling point.“I think his patience, and then his burst after he makes a decision on where he wants to go. I think he’s a 5,000-yard rusher or something like that. Obviously very talented.”For Ohio State to succeed against Washington, it may not just come down to stopping a previous Heisman contender in Browning. It likely will come down to the run game, with Gaskin being the key contributor.But for Borland, the Huskies’ offense reminds him of one of Ohio State’s recent opponents, one the Buckeyes had no problem handling on their way to the Big Ten Championship Game.“Their identity, their M.O., lies behind their running backs and O-Line,” Borland said. “Personnel-wise, they do some things similar to [Michigan], multiple tight ends. They utilize the running backs well.”
Former Liverpool defender Daniel Agger has admitted that he misses playing at Anfield after featuring in the legends game against Bayern Munich on SaturdayThe former Denmark international retired from professional football in 2016 at the age of 31 years old and has now suggested that he limits himself to only kicking a ball when playing alongside past players.Agger has revealed that what he misses most is playing in the atmosphere of Anfield:”It’s just being in a game, feeling the atmosphere and playing for something.Report: Origi cause Klopp injury concerns George Patchias – September 14, 2019 Divock Origi injury in today’s game against Newcastle is a cause for concern for Jurgen Klopp.Perhaps with one eye on Tuesday’s trip to Italy…“When you get out of football, it’s difficult to reproduce that in anything you do. That has been the hardest thing for me. It’s always nice to see the guys and to play alongside them is even better.“The most important thing was the show and the cause, helping the foundation. It was hard but it’s always nice to be back, especially in front of a full house. I haven’t touched the ball since the Sydney trip last year, so it was nice to touch it again but it’s getting harder and harder.” said Agger, according to the club website.In a eight year spell with Liverpool, Agger made 232 appearances across all competitions and won the Football League Cup back in 2012. The 33 year-old left in 2014 to rejoin Danish side Brondby, before announcing his retirement at the end of his contract with the club.
Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 23 Oct 2015 – The International Monetary Fund has advised the Financial Services Commission to keep an eye on one local bank, saying they are dissatisfied with how that bank has issued loans in the past. The IMF report said “weak governance in one large bank is an important vulnerability, so the FSC should remain vigilant.”The information emerges from a report by the IMF while in country this past April, and while the caution sounds foreboding the IMF reassures residents that there is no threat to depositors’ funds.It is just one of the many recommendations in 46 page report by the IMF where it is also suggested that the Government, “consider providing financial support to policy holders of the recently failed life insurer in order to protect the credibility of life insurance for long-term savings.”Over 2,600 policy holders held accounts with British Atlantic Financial Services Ltd, BAFSL when the company was liquidated earlier this year. The Premier had promised help, but insurers received only pennies on the dollar after the liquidation and decades of saving with the company. FSC secures membership world organization Nigueal Streete to take reigns of FSC with Higgins departure NEMA predicts Hurricane Irma will hit Bahamas and TCI on Thursday Related Items:bafsl, financial services commission, International Monetary Fund, liquidation, warning Facebook Twitter Google+LinkedInPinterestWhatsApp
Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, TCI, January 25, 2017 – The search for victims from a capsized sloop in waters off Northwest Provo was suspended last night, it resumes this morning says Police Press Officer, Kevin Clarke.Ten bodies were discovered and this is revealed to us last night as seven females, three males and the images of the bodies partially submerged in the sand, partially clothed, some where the drowned are completely naked, stiff and even their skin badly shredded, likely by the reef and marine animals are gut wrenching, heart breaking and unfortunately in social media circulation.This latest tragedy has caused National Security chiefs to put together a special media meeting; it is set for today and includes the Governor, Premier, Deputy Premier and Police Commissioner. Bahamas joint effort recovers more bodies of Haitian migrants Nearly 30 Haitians caught following illegal landing in Nassau, says Defence Force TCI on Alert as riots rage in Haiti, two-year president asked to resign Related Items:#Haitianboattragedy, #MagneticNewsMedia #MagneticNewsMedia #Haitianboattragedy Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsApp
WILMINGTON, MA — Wilmington Music Teacher and WHS Alum Michael Ferrara conducts a wind band that performs on the Town Common during the Fun on the Fourth celebrations.The band, which initially started as an “alumni band,” has expanded to include other members from the community.If you’re a musician (high school age or older) who would like to perform with the band, please contact Ferrara at Michael.Ferrara@wpsk12.com.The band is scheduled to perform this year on Friday, June 29 at 6pm.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… Related5 Things To Do In Wilmington On Monday, August 19, 2019In “5 Things To Do Today”VOLUNTEERS NEEDED: WCTV Looking For Camera Operators & Commentators For WHS Fall SportsIn “Community”VIDEO: Wilmington Fun On The Fourth HighlightsIn “Videos”
Share Carol Guzy/ZUMA PressWhen Hurricane Maria devastated Puerto Rico in September 2017, the island lacked the financial resources to make a fast recovery on its own.Before Hurricane Maria hit last September, Puerto Rico was battered by the forces of another storm — a financial storm.The island’s own government borrowed billions of dollars to pay its bills, a practice that Puerto Rico’s current governor, Ricardo Rosselló, now calls “a big Ponzi scheme.”But it didn’t fall into financial ruin all on its own: Wall Street kept pushing the Puerto Rican government’s loans even as the island teetered on default, with a zeal that bank insiders are now describing with words like “unethical” and “immoral.”NPR and the PBS series Frontline spent seven months looking into Puerto Rico’s difficult recovery from Hurricane Maria. And beneath the storm damage we found the damage from those economic forces, triggered by a government desperate for cash and banks and investment houses on Wall Street that made millions off that desperation. Some of those banks found ways to make even more money that risked the financial future of not only the island but thousands of residents as well.Carol Guzy/ZUMA PressJaime Degraff sits outside on Sept. 23, 2017, as he waits for the Puerto Rican electrical grid to be fixed after Hurricane Maria. The island is still struggling with power outages.‘Puerto Rico Is In Dire Need’Riding up the rickety elevator to the top of the Palo Seco power plant just outside San Juan, this convergence of natural and economic forces was apparent. As engineers fought to turn the plant back on and restore electricity to the island, weeds and rusted steel revealed decades of government neglect.“There are elements that have not been replaced in years,” said José Sánchez, then the head of power grid restoration for the U.S. Army Corps of Engineers. “Puerto Rico is in dire need, not only of power plants but a reconstruction of the grid itself.”And it wasn’t just the power grid. Water pumping stations, bridges, levees, roads — all had been starved for investment for years. Even people’s homes weren’t as strong as they should have been. Before the storm, the island could afford only five building code inspectors, for a population of 3.5 million people.Banks involved in Puerto Rican finances declined NPR and Frontline‘s requests for an interview but said in statements that they have done nothing but try to help Puerto Rico when it was in need of money.One thing that is clear: The island needed more help than it got.“We’ve gone through not only Maria, but we’ve gone through the financial crisis,” said top Puerto Rican banker Carlos Capacete. “It doesn’t end. And there’s no help coming. In the financial crisis, [Puerto Ricans] are the ones left holding the bag here. There was no life raft in the plane.”‘Down The Rabbit Hole’It wasn’t always this dire. For decades, Puerto Rico’s economy was booming. A special tax break on the island lured in pharmaceutical companies and manufacturers.Then in 1996 Congress started phasing out the tax break, and a decade later the island spun into recession. Rather than cut spending to make up for declining tax revenue, the Puerto Rican government went the other way. It borrowed money.“When you start borrowing long term just to pay next month’s payroll you know you are going down the rabbit hole,” said Sergio Marxuach, the policy director for the nonprofit Center for a New Economy in Puerto Rico.“It was crazy,” he said. “The government was borrowing at an incredible clip.”Like most governments, Puerto Rico preferred to borrow money through the sale of bonds. The island would take an investor’s money and essentially give him an IOU — a promise to pay the money back with interest. Investors liked the deal because they could earn that interest tax-free.Banks liked the deal too. They stepped in to structure the bonds and find buyers — often pension funds, retirement accounts, maybe the bank’s own investment clients — all in exchange for fees.“Fund managers, they will not admit this now, but when Puerto Rico was selling debt like pancakes, they loved Puerto Rico debt,” Marxuach said. “You would put … these Puerto Rico bonds into your portfolio and since they had slightly higher interest rates and no taxes attached to them, you immediately looked like a genius. You just bumped up the entire return.”“So that’s your bonus,” he added. “That’s your new Mercedes, your new yacht.”NPR and Frontline talked with more than a dozen bankers, advisers and brokers involved in Puerto Rican bonds who described a fast pace of moneymaking and competition, and politicians desperate for an influx of cash.“All the major banks in New York would come to Puerto Rico on a regular basis to pitch deals,” said Capacete, a former branch manager for UBS, the largest broker-dealer in Puerto Rico. “They make commissions. They make fees. This is kind of like a moneymaking machine. As long as there are transactions coming and going, they’re making a ton of money.”But Capacete said that in 2011, he and other bankers started realizing what many bond investors hadn’t yet figured out: Puerto Rico was in trouble. There was too much debt. And instead of moving away from bonds — and keeping the shaky investments out of their clients’ portfolios — Capacete says the opposite happened. He said banks pushed brokers to sell more bonds.Many of the bonds were specifically designed to be sold to Puerto Ricans, packaged into special funds that were less transparent than anything regulators would allow on the mainland. Regulations against things such as banks recommending their own bond deals to investors didn’t apply on the island.According to court records filed in the aftermath of the island’s economic calamity, brokers sold thousands of Puerto Ricans these special funds. This left hundreds of millions of dollars of the island’s wealth concentrated in increasingly tenuous investments — at the worst possible time.And then, Capacete says, he learned it was even worse than it looked. He says a client warned him that some brokers on the island were pushing Puerto Rican investors — who already had so much of their retirement or personal savings in these special funds — to borrow still more money, and invest that in the funds too. He says he sent emails complaining to the bank.“It’s unethical, it’s against the banks’ regulations and it puts the client in a really, really tough risk situation,” Capacete said.UBS declined NPR and Frontline‘s request for an interview but said the loan terms were fully disclosed to clients and that Capacete is a disgruntled former employee who has sued the bank. The bank said the loan program as a whole did not violate financial regulations, but that it had fired the one broker it discovered had been using the program incorrectly. And it pointed to a separate case where federal regulators determined the bank had not misled its customers.Eventually federal regulators investigated and found the bank should have had a system in place to prevent the practice. They fined UBS $34 million for the loan scheme and other problems. They also fined UBS and four other banks for putting clients at risk in the special Puerto Rican funds.The party came to an end for investors in 2013. Bond prices tanked. All those thousands of investors tied up in the same Puerto Rican funds were in serious trouble, and those who had taken out additional loans suddenly had to cover them.Within months, hundreds of millions of dollars in Puerto Rican wealth was wiped out. Rating agencies downgraded Puerto Rican bonds to junk.Looking back, Rosselló said at this point in the financial crisis it seemed like “the government of Puerto Rico was run as a big Ponzi scheme.”“What you had was essentially a black box of a government running, that had no clarity as to what was being borrowed and or what was being spent,” Rosselló said in an interview with NPR and Frontline.‘The Banks Get Out’Once again, at a time when you might think Puerto Rico and the banks would turn away from the bond business, they did the opposite. In 2014, Puerto Rico and a group of banks teamed up for another bond deal. At $3.5 billion, it was the largest municipal junk bond offering in U.S. history.Puerto Rican officials told NPR and Frontline they needed the cash to make payroll.But some bankers and brokers, several of whom worked on the deal, described the 2014 bond as more than just a bond deal. They said it was also an exit strategy for the banks.Government records show banks had been lending Puerto Rico hundreds of millions of dollars and making other investments there in the years before the financial troubles began. And according to bond documents from the 2014 deal, nearly a quarter of the entire bond went to those banks.Almost $900 million raised from the bond issue didn’t go to Puerto Ricans — or even to keep the government afloat — but instead went to pay back loans, pay fees or eliminate risk of banks directly involved in putting the deal together.Barclays, which led the bond deal, received almost $500 million; Banco Santander received $99 million; JPMorgan, $74 million; Morgan Stanley, $24 million; among others.Neither Barclays nor any of the other banks involved in the deal would agree to an interview. In statements, banks said that they fully disclosed their financial stake in the deal and did not influence how Puerto Rico used the money. Morgan Stanley noted that it also extended Puerto Rico $250 million in credit after the bond.Axel Rivera, who worked at Morgan Stanley as a bond broker and financial adviser when the deal was done, said as the island got closer to default, banks were getting nervous.“They had much more [debt] than they wanted and they needed to unwind that,” Rivera said, adding that the bond deal allowed them to do that.“The banks get out, and everybody else gets stuck with the bill,” Rivera said. “Most of the general public didn’t understand what was going on. The darkness of this bond deal made a lot of people in Wall Street happy, but it was immoral in many ways.”Fifteen months later, Puerto Rico announced it couldn’t pay its debt. The island was broke.The bond funds crashed. Many Puerto Rican investors lost savings, retirement funds or their pensions. The government started closing hospitals. There was little money to shore up bridges or strengthen the electrical grid.And then, on Sept. 20, 2017, a Category 4 hurricane came barreling into Puerto Rico. The island was left to face the wrath of the storm in a place starved of investment for years by a government that had to borrow to pay its bills.PBS Frontline‘s Emma Schwartz, Kate McCormick and Rick Young contributed to this report.Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Date: Saturday, Dec. 15Time: 11:30 a.m. ETSite: KFC Yum! Center Louisville, Ky. (22,000)Radio: WKRD-790, Nick Curran, play-by-play; Adrienne Johnson, analystVideo: ACCNE, Jim Kelch, play-by-play; Cortnee Walton, analystPromotion(s): 2009 Final Four Recognition, Final Four Rally Towel GiveawayLast Meeting: L, 71-60 (Nov. 25, 1989 at NKU)Series History: 9-10 (5-2 Home, 3-7 Away, 1-1 Neutral)UofL National Ranking: 4th Associated Press, 3rd USA TodayOfficials: Karen Preato, Maj Forsberg, Fatou Cissoko-StephensFor the latest on Louisville women’s basketball, visit GoCards.com, follow the team’s Twitter account at @UofLWBB or on Facebook at facebook.com/UofLWBB. Print Friendly Version Story Links Tickets Live Stats Durr was named ACC Player of the Week for the second-consecutive week after averaging 28.5 points per game in wins over UT Martin and Kentucky. She shot 49 percent from the floor, while averaging 3.0 assists, 3.5 rebounds and 2.0 steals. She has been named ACC Player of the Week nine times in her career, which is the active ACC record. She has earned the accolade three times this season, previously being honored on Nov. 12 and Dec. 3. She was named ACC Player of the Week on Dec. 3 after averaging 20.0 points, 4.7 assists and 4.0 rebounds, while shooting 51 percent from the floor, in home wins over Miami (Ohio), Nebraska and Tennessee State. She also earned the honor at the end of the first week of the season after averaging 28.5 points per game in wins at Western Kentucky and Chattanooga.Durr has 1,971 career points and is 29 points away from becoming the fourth player in program history to reach 2,000 points. Series History – UofL is 9-10 all-time against Northern Kentucky and 5-2 at home. This marks the first matchup between the two teams since Nov. 25, 1989 when the Cardinals fell 71-60 at NKU. The series record is now 20-34 and head coach Jeff Walz’s record is 6-6 against Kentucky. Louisville moved up to No. 3 in the USA Today/Coaches Poll. It marks their highest ranking since they held the No. 3 spot the weeks of March 5 and 12 last season. Last year, they tied a program-high by reaching No. 2 on Jan. 15 after beating Notre Dame, 100-67. It marks the earliest they have reached No. 3 since the 2013-14 season when they reached No. 3 on Nov. 18. Walz graduated from Northern Kentucky in 1995 and lettered two seasons for their basketball team. It marks the first time that he will face his alma mater. LOUISVILLE, Ky. – University of Louisville women’s basketball (No. 3/4, 10-0) concludes its six-game homestand when it hosts Northern Kentucky (1-5) on Saturday at 11:30 a.m. ET. With the 80-75 win over Kentucky on Sunday, the Cardinals moved to 10-0 on the year. Five players scored in double figures in the win over Kentucky (Asia Durr – 32, Sam Fuehring – 12, Jazmine Jones – 12, Bionca Dunham – 11, Dana Evans – 10). Seven active players are averaging more than 7.4 points per game and 17.7 minutes per game. Overall, at least 11 players have played in seven of 10 games, and at least nine have scored in six games. Against UT Martin, she posted 25 points on 8-of-18 shooting, including 3-of-6 from beyond the arc and 6-of-6 from the foul line, while adding five rebounds, three assists and three steals. She followed that with 32 points on 13-of-25 shooting against Kentucky, opening the game with Louisville’s first seven points in route to a 15-point first quarter. Listen Louisville outscored UK 42-28 in the paint and has outscored their opponent down low in nine of 10 games this season. The only game where they were outscored in the paint was against Hartford (28-38). They had a season-high 54 points in the paint against UT Martin and are averaging 39.6 per game. Watch Media Center For just the third time in the 54-game series, UofL has won three straight games over UK. The victory follows an 87-63 win last season in Lexington on Dec. 17, 2017 and a 69-67 overtime win at the KFC Yum! Center on Dec. 4, 2016. They also won three straight in 1979 (W, 51-49, 1/8/79; W, 68-67, 2/6/79; W, 65-61, 3/3/79) and five straight from 2004 to 2008. PromotionsFinal Four Rally Towels – First 1,000 fans will receive a Rally Towel featuring the 2009, 2013 and 2018 Final Four banners.Welcome Back the 2009 Final Four Team – Join us in celebrating the 10th anniversary of the 2009 Final Four team. The team will be recognized at halftime and several players, including Angel McCoughtry, will be in attendance. ABOUT THE NORSELast year, Northern Kentucky went 9-22 overall and 6-12 in Horizon play. The Norse have opened this season with a 1-5 record, their lone win a 73-32 victory over Alderson Broaddus (DII, Phlippi, W. Va.). In their last two games, they have lost by a combined nine points to Austin Peay (L, 52-48) and Illinois State (L, 58-53). They feature seven players averaging more than 5.5 points per game, led by freshman guard Taylor Clos, who is averaging 10.3 points per game.
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org To better understand the structure-metabolism relationship between functional groups and AOX as well as to establish general guidelines for non-cytochrome P450 drug metabolism, researchers from the University of Perguia in Italy conducted tests on 198 compounds with aza-aromatic scaffolds to see which ones were oxidized by AOX. Furthermore, they tested 75 amide scaffolds to determine which ones were hydrolyzed. They found that electronic factors as well as steric hindrance affected the molecule’s orientation in the MoCo active site, which determined whether the compound was metabolized by AOX. Their work appears in the Proceedings of the National Academy of Sciences.AOX is an enzyme located in the liver that tends to oxidize aza-aromatic compounds as a phase I metabolite. Studies have shown that AOX activates the unsubstituted carbon ortho to the nitrogen on the aza heterocycle. Because this is the most electropositive carbon of the aromatic ring, electron density likely plays a role in AOX activation. But these studies, as well as others that look at AOX metabolism, were based on a small number of molecules that does not allow for deducing a general pattern for structure-metabolism relationship. In the current study, Lepri et al. tested 198 aza-aromatic compounds to see if they were oxidized by AOX. Each of these had typical aza-aromatic scaffolds with variations on electron withdrawing and electron donating substituents. They either acquired or made this catalog of compounds and then conducted in vitro metabolism studies using human liver cytosol.DFT calculations were used to elucidate the effects of electron density for AOX activity. The site of metabolism on the aromatic compound tended to correspond to the most electro-positive unsubstituted carbon, as expected. Additionally, computations studies were used to conduct docking analysis of the compounds in the active site of AOX. The authors found some trends for the site of metabolism; however, these trends are complicated by several factors. The pyridine scaffold was the only one that, as a scaffold class, was not susceptible to AOX metabolism. The other groups strongly depended on the electron density on particular carbons or, as the authors found with compounds such as quinoxalines and certain bicyclic compounds, steric hindrance in the active site prevented AOX metabolism.Lepri et al. also tested 73 amide compounds to see if AOX hydrolyzed the amide bond. In general, if there was an electron withdrawing group in the ortho position on the analine, then AOX did not oxidize it. If there was an electron donating group, then it did. The meta and para versions of electron donating and electron withdrawing groups were not susceptible to AOX metabolism.Exposure effects were an important component to whether a compound was metabolized by AOX. This has to do with the molecule’s orientation toward the MoCo center in the AOX active site. Certain bulky groups resulted in no activity where one was expected based on computational studies. Additionally, hydrophobicity also affected how the compound interacted with the active site. When the reactive carbon is exposed to the MoCo center, then the compound is easily metabolized. But, when the unreactive portion of the compound is oriented toward the MoCo center, then the compound is less likely to be oxidized or hydrolyzed.The authors point out that from these experiments “it emerges that it is not at all simple to predict whether a compound is a substrate of AOX or not.” The difficulty lies in understanding the reactivity of the electrophilic carbon on the compound as well as how that particular compound will orient itself in the enzyme’s active site. However, this study provides a starting point for additional studies and more sophisticated modeling techniques. More information: Susan Lepri et al. Structure–metabolism relationships inAOX: Chemical insights from a large database of aza-aromatic and amide compounds, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1618881114AbstractAldehyde oxidase (AOX) is a metabolic enzyme catalyzing the oxidation of aldehyde and aza-aromatic compounds and the hydrolysis of amides, moieties frequently shared by the majority of drugs. Despite its key role in human metabolism, to date only fragmentary information about the chemical features responsible for AOX susceptibility are reported and only “very local” structure–metabolism relationships based on a small number of similar compounds have been developed. This study reports a more comprehensive coverage of the chemical space of structures with a high risk of AOX phase I metabolism in humans. More than 270 compounds were studied to identify the site of metabolism and the metabolite(s). Both electronic [supported by density functional theory (DFT) calculations] and exposure effects were considered when rationalizing the structure–metabolism relationship. Cytochrome P450 synthetic analogs are temperature-dependent valence tautomers Citation: Toward a better understanding of structure-metabolism relationships in human aldehyde oxidase (Update) (2017, May 2) retrieved 18 August 2019 from https://phys.org/news/2017-05-structure-metabolism-relationships-human-aldehyde-oxidase.html Journal information: Proceedings of the National Academy of Sciences (Phys.org)—Drug design involves guided trial-and-error. How the body metabolizes a particular drug is important for determining drug efficacy. There have been many studies to understand how xenobiotics interact with cytochrome P450s, an important class of enzymes in drug metabolism, but little research has been done to understand aldehyde oxidase (AOX) metabolism. AOX, located in the liver, plays an important role in drug metabolism; however, many potential drugs end up failing during late-stage trials because of their interaction with AOX. Explore further Examples of the studied aza-aromatic scaffolds: the number of tested compounds is reported in brackets. Credit: (c) Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1618881114